|
Symbol Name ID |
Smad4
SMAD family member 4 MGI:894293 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Diabetes mellitus |
Exocrine pancreatic insufficiency |
Neoplasm of the pancreas |
Pancreatic adenocarcinoma |
Pituitary adenoma |
Neoplasm of the thyroid gland |
| Disease(s) Associated with SMAD4 | ||||||
| Lynch syndrome | ||||||
| pancreatic cancer |
| Mouse Phenotypes | endocrine/exocrine gland phenotype |
small thymus |
enlarged sebaceous gland |
abnormal ovarian follicle morphology |
abnormal granulosa cell morphology |
increased secondary ovarian follicle number |
decreased tertiary ovarian follicle number |
abnormal ovarian folliculogenesis |
abnormal cumulus expansion |
absent cumulus expansion |
abnormal secondary ovarian follicle morphology |
small seminiferous tubules |
seminiferous tubule degeneration |
increased Leydig cell number |
decreased testis weight |
small testis |
increased ovary tumor incidence |
abnormal thymus physiology |
|
| Availability | Mouse Genotype | ||||||||||||||||||
| Smad4m4Mag/Smad4+ | |||||||||||||||||||
| Tg(Amh-Smad4)1Tkw/0 | |||||||||||||||||||
| Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ (conditional) |
* | ||||||||||||||||||
| Smad4tm1Rdp/Smad4tm1Rdp Tg(Pdx1-cre)89.1Dam/0 (conditional) |
* | ||||||||||||||||||
| Ptf1atm1.1(cre)Cvw/Ptf1a+ Smad4tm1Rdp/Smad4tm1Rdp (conditional) |
* | ||||||||||||||||||
| Smad4tm2.1Cxd/Smad4tm2.1Cxd Tg(Foxn1-cre)8Ghr/0 (conditional) |
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| Smad4tm2.1Cxd/Smad4tm2.1Cxd Tg(Krt1-15-cre/PGR*)22Cot/0 (conditional) |
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| Amhr2tm3(cre)Bhr/Amhr2+ Smad4tm1Rob/Smad4tm1.1Rob (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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